太阳成集团tyc33455cc
         


教   授    

陈付学,男,博士,教授,博士生导师。太阳成集团tyc33455cc常务副院长。

19997月博士毕业于西北农林科技大学动物遗传育种与繁殖专业。20012003年间在美国Georgia State University 从事细胞与分子生理学博士后研究工作。主持或以主要学术骨干参加科技部“973”、教育部留学归国人员基金、上海市自然科学基金、上海市教委重点创新项目、上海市农委攻关项目多项。讲授“动物学”、“神经生物学技术”、“生命科学导论”、“现代生物技术导论”等课程。荣获 “上海大学优秀青年教师”、“上海市优秀青年教师”称号。

电话:021-66135167

邮箱:chenfuxue@staff.shu.edu.cn

教育与工作经历:

1996/09-1999/07 西北农林科技大学,动物科学学院,获博士学位;1993/09-1996/07贵州大学,动物科学系,获硕士学位;1989/09-1993/07 西北农林科技大学,畜牧系,获学士学位。

2010/03-至今 上海大学 太阳成集团tyc33455cc 教授;2003/03-2010/02 上海大学 太阳成集团tyc33455cc 副研究员;2001/12-2003/03 美国佐治亚州立大学 博士后;1999/07-2003/02 上海大学 太阳成集团tyc33455cc 讲师。

主要研究领域: 儿童自闭症基因编辑动物模型构建、自闭症分子生物学机制研究、恶性脑胶质瘤发生发展过程中信号通路的分子机制。

代表性研究成果:初步阐明了sat3等基因在恶性脑胶质瘤发生发展中的分子生物学机制;筛选出一些儿童自闭症易感基因,并构建了基因编辑动物模型。

近五年代表性论文:

[1]     Rescuing Kv10.2 protein changes cognitive and emotional function in kainic acid-induced status epilepticus rats. Epilepsy & Behavior,(accept)

[2]     Increased Expression of Kv10. 2 in the Hippocampus Attenuates Valproic Acid-Induced Autism-Like Behaviors in Rats. Neurochemical research, 44(12), 2796-2808,201912

[3]     Central changes in the Kv10.2 potassium channel in stress-induced hypertension rats, Neuroreport, 30(9):637-644,201906

[4]     Melatonin decreases M1 polarization via attenuating mitochondrial oxidative damage depending on UCP2 pathway in prorenin-treated microgliaPLoS One142),201902

[5]     Quantitative Structure-activity Relationship of Acetylcholinesterase Inhibitors based on mRMR Combined with Support Vector RegressionLett Org Chem164):311-316201902

[6]     Berberine activates bitter taste responses of enteroendocrine STC-1 cellsMol Cell Biochem4471-2):21-32201810

[7]     Role of microglia M1/M2 polarisation in the paraventricular nucleus: New insight into the development of stress-induced hypertension in ratsAuton Neurosci21371-80201809

[8]     Knockdown of Diaph1 expression inhibits migration and decreases the expression of MMP2 and MMP9 in human glioma cellsBiomed Pharmacother96596-602201712

[9]     CREB1 regulates glucose transport of glioma cell line U87 by targeting GLUT1Mol Cell Biochem4361-2):79-86201712

[10]  Small molecular floribundiquinone B derived from medicinal plants inhibits acetylcholinesterase activityOncotarget834):57149-57162201708

[11]  Prediction of the aquatic toxicity of aromatic compounds to tetrahymena pyriformis through support vector regressionOncotarget830):49359-49369201707

[12]  A Cancer Gene Selection Algorithm Based on the K-S Test and CFSBiomed Res Int201705

[13]  Prediction of an Interaction Between Bakuchiol and Acetylcholinesterase Using AdaboostCurr Bioinform111):79-862016

[14]  Bitter taste receptor mTas2r105 is expressed in small intestinal villus and cryptsBiochem Biophys Res Commun4634):934-941201508

[15]  Structural Characterization and Neurotrophic Activity Study of a Polysaccharide Isolated from Campanumoea javanicaJ Carbohydr Chem 344): 183-195201505

[16]  Expression of bitter taste receptor Tas2r105 in mouse kidneyBiochem Biophys Res Commun4584:733-738201503

[17]  67kDa laminin receptor regulates the activation of MAPKs through DUSPs in glioma cell line U251J BUON201:253-260201501

[18]  Knockdown of PKC epsilon Expression Inhibits Growth, Induces Apoptosis and Decreases Invasiveness of Human Glioma Cells Partially Through Stat3J Mol Neurosci 551:21-31201501

地 址:上海市宝山区南陈路333号太阳成集团tyc33455cc
网址 www.hifigz.com
邮 编: 200444

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