办公室：上海大学宝山校区东区19号楼528室

E-mail： lshi@shu.edu.cn

个人简介

2016年于山东大学获得生物技术和英语双学士学位，2019年、2022年于南京大学太阳成集团tyc33455cc分别获得硕士和博士学位，曾连续三年获得研究生国家奖学金，并获得2019年“南京大学学生年度人物”、2022年“南京大学优秀毕业生”、2022年“江苏省优秀毕业生”、2023年“南京大学优秀博士学位论文”、2023年“江苏省优秀博士学位论文”等荣誉和称号。2022年进入太阳成集团tyc33455cc从事博士后研究工作，获批2022年全国“博士后创新人才支持计划” 和2022年“上海市超级博士后”等项目。目前在SCI刊物上已正式发表23篇研究性论文，其中11篇以第一/通讯作者的身份发表在国际学术期刊上，包括J. Am. Chem. Soc.、Nano Lett.、Anal. Chem.、Biosen. Bioelectron.、ACS Appl. Mater. Interfaces等期刊，申请了5项国家发明专利、2项已授权，作为章节作者参与Elsevier邀稿专著“Nano-inspired biosensors for protein assay with clinical applications”的撰写。

代表性论文：

1. Liu Shi, Beibei Nie, Lingjun Sha, Keqin Ying, Jinlong Li, Genxi Li. Graphene Oxide-Mediated Regulation of Volume Exclusion and Wettability in Biomimetic Phosphorylation-Responsive Ionic Gates. Nano Lett. 2023, 23: 10326-10333

2. Liu Shi, Deqi Kuang, Xuemei Ma, Mohammed Jalalah, Saeed A. Alsareii, Tao Gao, Farid A. Harraz, Jie Yang, and Genxi Li. Peptide Assembled in a Nano-confined Space as a Molecular Rectifier for the Availability of Ionic Current Modulation. Nano Lett. 2022, 22: 1083-1090

3. Liu Shi, Chaoli Mu, Tao Gao, Wenxin Chai, Anzhi Sheng, Tianshu Chen, Jie Yang, Xiaoli Zhu, and Genxi Li, Rhodopsin-Like Ionic Gate Fabricated with Graphene Oxide and Isomeric DNA Switch for Efficient Photocontrol of Ion Transport. J. Am. Chem. Soc. 2019, 141: 8239-8243

4. Liu Shi, Keqin Ying, Lingjun Sha, Yuanyuan Zhang, Lizhou Sun, Genxi Li. DNA-Peptide Interaction-Modulated Charge Reversal in Biomimetic Nanochannels for Simple and Efficient Detection of Histone Deacetylase Activity. Anal. Chem. 2024, 96: 4817–4824

5. Liu Shi, Lin Wang, Xuemei Ma, Xiaona Fang, Liangliang Xiang, Yongxiang Yi, Jinlong Li, Zhaofeng Luo, Genxi Li. Aptamer-Functionalized Nanochannels for One-Step Detection of SARS-CoV-2 in Samples from COVID-19 Patients. Anal. Chem. 2021, 93: 16646-16654

6. Liu Shi, Xuemei Ma, Haojie Xie, Yujia Qin, Yue Huang, Yuanyuan Zhang, Lizhou Sun, Jie Yang, Genxi Li. Engineering m6A demethylation-activated DNAzyme for visually and sensitively sensing fat mass and obesity-associated protein. Biosen. Bioelectron. 2023, 222: 115007

7. Liu Shi, Fengjie Jia, Lin Wang, Mohammed Jalalah, Tao Gao, Farid A. Harraz, Genxi Li. Fabrication of an artificial ionic gate inspired by mercury-resistant bacteria for simple and sensitive detection of mercury ion. Sens. Actuators B Chem. 2021, 326: 128976

8. Liu Shi, Lin Wang, Xuemei Ma, Mohammed Jalalah, Saeed A. Alsareii, Tao Gao, Farid A. Harraz, Genxi Li. Electrochemical Trans-Channel Assay for Efficient Evaluation of Tumor Cell Invasiveness. ACS Appl. Mater. Interfaces 2021, 13: 17268-17275

9. Liu Shi, Chaoli Mu, Tao Gao, Tianshu Chen, Shuang Hei, Jie Yang, Genxi Li, DNA nanoflower blooms in nanochannel: a new strategy for miRNA detection. Chem. Commun. 2018, 54: 11391-11394

10. Liu Shi, Lin Wang, Xiaomeng Yu, Deqi Kuang, Yue Huang, Nana Yang, Jie Yang, Genxi Li. Colorimetric detection of furin based on enhanced catalytic activity of G-quadruplex/hemin DNAzyme. Anal. Chim. Acta 2024, 1323: 343070

授权发明专利：

基于石墨烯盖子与仿生DNA相互作用的高效光调节离子门控，发明专利，ZL 2018 1 1514485.0

一种基于通道内生成DNA纳米花的miRNA检测装置，发明专利，ZL 2018 1 0453521.0

研究领域

生化分析与生物传感